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Our solution
Our company
Sakura Bio is a start-up company developing an off-the-shelf, allogeneic T-cell therapy to fight cancer.
Our lead product, SAK-T (Super Activated Killer T-cell), is a unique T-cell population with superior anti-tumor cytotoxic activity and no toxicity of healthy tissue.
The technology was established by Professor Amnon Peled and Dr. Inbal Mishalian at Hadassah Medical Center, and involves a simple, cost effective, proprietary manufacturing process.
In contrast to other T-cell based products, such as CAR-T, SAK-T cells have High safety profile, with no Graft-versus-host disease (GVHD), and can be developed as an off-the-shelf T cell product.
Comprehensive preclinical studies validated the killing superiority of SAK-T vs. CIK and other T-cell-based therapies in different tumor models.
SAK-T outstanding killing properties of leukemic cells lead Sakura to choose Acute Myeloid Leukemia (AML) as its first-in-man indication for SAK therapy.
OUR TEAM
Our team
ADVISORY BOARD
Board of directors
our science
our science
The technology
* SAK-T: Super Activated Killer T cells
The technology
THE NEED
AML
Acute myeloid leukemia (AML) is a cancer of the blood cells derived from the uncontrolled proliferation and maturation of myeloid progenitor cells.
The American Cancer Society estimates that in the United States in 2022 there will be about 20,000 new cases of AML and about 11,500 deaths, almost all in adults.​
AML is a life-threatening haematological malignancy; the 5-year survival of patients is disappointingly low, ~ 30%.
The first-line treatment of AML is usually chemotherapy, sometimes along with a targeted therapy drug. This might be followed by a stem cell transplant derived from a healthy donor.
However, 50% of all patients who achieved remission of the disease after initial treatment relapse, due to minimal residual disease (MRD). MRD refers to a small number of cancer cells left in the body after treatment that have the potential to cause relapse of the disease.
About 25% of the relapsing patients (mainly elder patients) cannot undergo additional chemotherapy treatment or stem cell transplant due to their physiological conditions.
Currently, there is no available safe second-line treatment for those patients.
Sakura bio’s SAK-T based therapy can provide a safe and effective solution for MRD-positive AML patients which are transplantation ineligible.
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