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Our Technology
T-Boost:
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Despite the transformative potential of cell therapy, relapse rates following CAR-T treatment remain unacceptably high: 30-50% of patients relapse within the first year. This is largely driven by antigen loss, limited T-cell persistence, and functional exhaustion within the hostile tumor microenvironment. To improve clinical outcomes, there is a pressing need for more durable, potent, and resilient immune cells.
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Sakura Bio has developed T-Boost, a proprietary platform that uniquely reprograms T and NK cells during the manufacturing process to enhance their potency, persistence, and resistance to the tumor microenvironment, directly addressing key limitations of current CAR-T and other cell therapies.
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T-Boost is a modular, plug-in technology compatible with a wide range of modalities, including CAR-T, TCR-T, CAR-NK, TILs, and next-generation platforms for both solid and hematologic tumors.
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Backed by strong preclinical data, T-Boost offers a scalable, platform-level opportunity to improve clinical outcomes and address major pain points in a fast-growing global cell therapy market.
T-Boost
T-Boost
A proprietary platform technology enabling reprograming
of T/NK-cell functionality and strengthening cell therapies
Superior Characteristics
＋Increased resistance to the tumor microenvironment (TME)
＋Enhanced potency & cell persistence against blood cancers & solid tumors
＋Improved metabolic fitness, cellular energy & durability
＋Preferential lymph node homing ensures long-lasting responses
＋Applicable for both allogeneic (donor-derived) & autologous (patient-derived)
＋Cost effective & simple production process
THE PROCESS
T-Boost, The Secret Sauce:
Growth Factors, Antibodies, Small Molecules and Timing
T-BOOST: A PLUG-IN PLATFORM TECHNOLOGY
T-Boost can function as a stand-alone product or be seamlessly integrated into partners’ products, making them stronger, more effective, and successful.
It is the ONLY true plug-&-play solution for any cell therapy company
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